The Deepwater Horizon Oil Spill was a catastrophic event that triggered the collection of thousands of samples. This required immediate decisions as to how the environmental data would be assembled from a large number of analytical laboratories, and managed such that the data would be accessible, usable, and comparable, while maintaining data integrity and defensibility. Through a collaboration between laboratories, NOAA Data Management Team, and EcoChem, millions of analytical records have been verified and validated; matched to the appropriate field data; and made available to the data users to support studies and assessments relating to the spill. Some of the challenges of managing such a large data set will be discussed, along with problem resolution procedures and lessons learned.