Deuterated Monitoring Compounds for Better Accuracy and Precision Measurement of GC/MS Environmental Data

Poster Presentation

Prepared by C. Appleby
U.S. Environmental Protection Agency, Office of Superfund Remediation and Technology Innovation, Analytical Services Branch, William Jefferson Clinton Building, 1200 Pennsylvania Ave., NW, MC5203P, Washington, DC, 20460, United States

Contact Information:; 703-347-0266


Last year, at NEMC, there was a presentation on the use of deuterated analogs of target compounds in GC/MS methods by the Contract Laboratory Program (CLP). EPA-approved GC/MS methods require the use of three to six compounds as surrogate standards; however, only a few are deuterated analogs of target analytes. Deuterated analogs are more representative of target analytes, thereby providing more information regarding matrix effects while measuring accuracy and can also be used to measure precision. Developed to improve data quality used in decision-making processes, this approach has reduced the cost to the Superfund Program. This poster presentation will show, with thousands of new data points, how incorporating more DMCs into EPA-approved GC/MS methods has improved data quality, and provided cost savings to the Agency, and how it may benefit the entire analytical chemistry community.