Just Go with the Flow: The Routine Application of GC×GC-TOF MS to Real-world Analyses

Oral Presentation

Prepared by D. Wevill1, L. McGregor2, N. Bukowski2, M. Santoro2, M. Edwards2, D. Wevill3, P. Grosshans4
1 - Markes, 2355 Gold Meadow Way, Gold River, CA, 95670, United States
2 - Markes International, Gwaun Elai Mediscience Campus, Llantrisant, RCT, CF728XL, United Kingdom
3 - Markes International, 2355 Gold Meadow Way, Suite 130, Gold River, CA, 95670, United States
4 - Markes, 11126 Kenwood Road, Suite D, Cincinnati, OH, 45242, United States

Contact Information: [email protected]; 866-483-5684


Comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry (GC×GC-TOF MS) has gained much popularity in recent years. The enhanced separation offered by the coupling of columns of complementary stationary phases has been proven to work well for a range of challenging samples, including petrochemicals, fragrances/food aromas and environmental contaminants.

While GC×GC-TOF MS has been heavily adopted in research and development labs, it is rarely applied for routine analyses, with many analysts believing it to be too complicated, fragile and/or expensive. Furthermore, the thermal modulation devices which have dominated GC×GC literature require a cryogen fluid to modulate volatiles in the C4-C8 range – meaning additional running costs and the extra hassle associated with health and safety management of the laboratory.

This presentation explores the use of flow-modulation in routine applications, as a simple, yet effective, method of gaining all the benefits of GCxGC-TOF MS without incurring any of the historical cost or hassles.