Nitrosamine Analysis in Drinking Water Using Triple Quadrupole GC/MS

Poster Presentation

Prepared by D. Wong, R. Honnold, C. Marvin
Agilent Technologies, 2850 Centerville Road, Wilmington, DE, 19808, United States

Contact Information: [email protected]; 302-559-1528


Nitrosamines, particularly NDMA, are a group of disinfection byproducts frequently detected in finished drinking water and of concern to environmental agencies. The U.S. EPA Office of Groundwater and Drinking Water (OGWDW) developed Method 521 in 2004 to provide a procedure for trace level analysis of seven nitrosamines in finished drinking water by solid-phase extraction and chemical ionization tandem mass spectrometry (MS/MS). Ion Trap GC/MS is the approved technology, but the system is being obsoleted. Through an interlaboratory study, we show that migration to GC-MS/MS systems provided significant improvements in speed and sensitivity. This work demonstrates a GC-MS/MS method to allow for monitoring at levels below the current LCMRL (lowest concentration minimum reporting level) set in Method 521. The GC-MS/MS method included the optimization of an additional nitrosamine, N-Nitrosomorpholine (NMOR). Three laboratories collaborated to produce the LCMRL and performance data required for an Alternate Test Procedure method update. Results from these laboratories are compared to evaluate method feasibility and reproducibility.