New SPE Disk for Determination of Multi-class Pharmaceutical and Personal Care Products Residues in Tap Water, Prior to HPLC-MS/MS Analyses

Challenges and Opportunities for Solid Phase Extraction
Poster Presentation

Presented by J. Fenster
Prepared by , M. Arotcarena, C. Germain, K. Naraghi, R. Durand

Contact Information: sdkearns@gmail.com; 603-401-9167


ABSTRACT

The presence of pharmaceuticals in drinking water, even at very low concentrations, has raised concerns among stakeholders such as drinking-water regulators, governments, water suppliers and the public, with regard to the potential risks to humans. There is a need for a sensitive and reliable analytical method for drug residues in drinking water.

A new SPE Disk based on HLB polymeric sorbent has been developed to improve extraction and concentration method from a liquid or air sample. This SPE disk is a very thin, soft, dense and uniform membrane having a high capacity without any channeling effect. In this work, this SPE Disk is used to clean-up and pre-concentrate multi-class pharmaceutical residues. Large-volume extractions were applied with high flow rate giving excellent recovery yields.

This method covers a wide range of polarities of pharmaceutical residues (in water systems, prior to HPLC-MS/MS analyses. The targeted pharmaceutical compounds list described in EPA Method 1694.