Elemental Speciation and Total Metals Analysis with a Single Platform

Poster Presentation

Prepared by

Contact Information: derrick.quarles@icpms.com; 402-991-7800


Species interconversion during sample collection and/or preparation prior to analysis has to be carefully monitored. Typical LC-ICP-MS experiments can be lengthy, resulting in hours of analysis time. Additionally, to minimize matrix loading and ensure good separation, samples typically need to be diluted. Not only can the simple process of diluting the samples effect metal species, the effect can vary with time. This study investigates whether inline autodilution immediately prior to the column at time of analysis can mitigate species interconversion and maintain the integrity of the original sample (i.e., no species interconversion). A comparison of traditional sample preparation versus inline dilution for arsenic species (AsB, DMA, MMA, As III, and As V) in urine will be presented.