Sensitive Detection of Trace Organic Contaminants in Water by 1290 Infinity II FlexCube Online SPE and Ultivo Triple Quadrupole LC/MS

Poster Presentation

Prepared by , T. Sosienski

Contact Information:; 1 408 553-7091


Trace organic contaminants (TOrCs) are compounds that are frequently found at low levels in the environment, and may not be completely removed from the drinking water treatment process. TOrCs are often unintentionally introduced to waterways from household and industrial drains, and runoff from residential and commercial areas. TOrCs include a wide variety of compound and contaminant classes such as pharmaceuticals, personal care products, pesticides, endocrine disruptors and industrial compounds. The effect of long term low levels of TOrCs in drinking water on human health is unknown, therefore methods for the detection of TOrCs in drinking water are of public interest. We have developed a sensitive and precise method for the analysis of TOrCs in drinking water using the Agilent 1290 Infinity II FlexCube Online SPE and the Ultivo Triple Quadrupole LC/MS. 51 TOrCs were monitored in a 21 minute analytical method, using a small 900µL injection of sample with no clean up or extraction. Analytes were retained using Agilent PLRP-S cartridges (2.1x 12.5mm, 15-20µm), and separated using an Agilent Poroshell 120 EC C18 (3.0 x 50 mm, 2.7 μm). Most of the analytes can be accurately quantified at single digit parts-per-trillion level using Ultivo in dynamic MRM mode.. This method delivered excellent linearity and precision, with %RSD < 20% for most compounds.