What, Exactly, is Total Organofluorine, and Why is it Important?

Polyfluoroalkyl Substances (PFAS) in the Environment
Oral Presentation

Prepared by N. Nigro1, J. Gandhi2
1 - Pace Analytical Services, LLC, 2525 Advance Road, Madison, WI, 53718, United States
2 - Metrohm USA, 1455 East Sam Houston Parkway South, Pasadena, TX, 77503, United States

Contact Information: nick.nigro@pacelabs.com; 608-221-8700


The concept of determining total organofluorine, or “TOF” as has been widely (and often incorrectly) used during the emergence of this topic, can be a powerful tool to determine the total PFAS concentration in a sample. However, before this tool can be appropriately used, a better understanding of the definition of TOF needs to be more widely understood. What is TOF, exactly, and how does it differ from total fluorine, adsorbable organofluorine, or extractable organofluorine? Is this what they mean by “managing PFAS as a class”? What are the various applications and uses of TOF testing? What are the various means to analyze for TOF? How does TOF testing compare to other total PFAS or non-targeted PFAS tools such as qTOF and TOP Assay? And do TOF results really mean that I have a lot more PFAS contamination in my sample? These questions will be answered in detail, walking attendees through a deep and broad understanding of the TOF marketplace. In addition, several recent examples will be presented, comparing TOF to AOF to targeted PFAS by isotope dilution. Attendees will come away with a much greater understanding of this tool, and the existing and emerging analytical solutions to support this critical testing need.