Advantages and Challenges of Automated Sample Preparation for the Extraction of PFAS from Drinking Water

Polyfluoroalkyl Substances (PFAS) in the Environment
Oral Presentation

Prepared by M. Giardina1, S. Wierer2, A. Köpf2
1 - Agilent Technologies, 2850 Centerville Rd, Wilmington, DE, 19808, United States
2 - LCTech GmbH, Daimlerstr. 4, Obertaufkirchen, Mühldorf, 84419, Germany


Contact Information: matthew_giardina@agilent.com; 302-636-8211


ABSTRACT

Most regulated methods for the analysis of PFAS compounds in drinking water require the use of solid phase extraction (SPE) to achieve low part-per-trillion reporting requirements. The SPE extraction protocol for these methods are highly dependent upon correct laboratory technique to achieve reliable results and ensure data quality. For a single operator, following the extraction protocol can be challenging especially when processing multiple samples at the same time. Reducing the potential of solution handling errors and allowing true parallel processing of multiple samples are substantial advantages of automation. However, the instrument must be carefully designed for PFAS analysis as not to cause sample contamination, losses, or carryover. In addition, all consumables required for the analysis throughout the sample handling workflow must be free from contamination or losses. These include the SPE cartridges, collection vials, autosampler vials, and LC-MS/MS systems. In this presentation, the results for the validation of the FREESTYLE XANA for the extraction of PFAS compounds in drinking water following EPA method 537.1 will be discussed in detail. An emphasis will be placed on understanding the advantages and challenges of automation on the complete sample handling workflow.