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Ultra-Sensitive Detection of Pharmaceutical and Personal Care Products (PPCPs) in Water with an Integrated On-Line Extraction-UHPLC-MS/MS System
Oral Presentation
Prepared by H. Sun1, Z. Yang2, K. Wang3
1 - Bruker, 3500 W Warren Ave, Fremont, CA - California, 94538
2 - Bruker, 3500 W Warren Ave, Fremont, CA - California, 94538
3 - Bruker, 3500 W Warren Ave, Fremont, CA - California, 94538
Contact Information: helen.sun@bruker.com; 510-683-4330
ABSTRACT
The occurrence of pharmaceutical and personal care products (PPCPs) in the environment water is of growing concern due to their potential harmful effects on environmental and human. The conventional methods based on the “template” of EPA 1694 method require pre-concentration of large volume of water sample and tedious SPE cleanup, followed by LC-tandem mass spectrometer analysis in order to achieve the low ng/L (ppt) level detection. In this study, we introduce an UHPLC system with an integrated online extraction option coupled to a Bruker EVOQ Elite triple quadrupole mass spectrometer for detection of PPCP’s in water. The Bruker Advance UHPLC OLE system consists of one binary pump and an integrated third pump for online sample preparation. The built-in online extraction requires no additional hardware assembly (LC pump and valve), and can readily detect 1-5 ppt of PPCPs in water by rapidly pre-concentrating 0.5 mL drinking water sample. The current ongoing work is focused on expanding the targeted PPCP list in one analytical run by further optimizing the pre-concentration step and improving chromatographic separation, which will be applied on the water samples from the local lakes in the bay area.
Oral Presentation
Prepared by H. Sun1, Z. Yang2, K. Wang3
1 - Bruker, 3500 W Warren Ave, Fremont, CA - California, 94538
2 - Bruker, 3500 W Warren Ave, Fremont, CA - California, 94538
3 - Bruker, 3500 W Warren Ave, Fremont, CA - California, 94538
Contact Information: helen.sun@bruker.com; 510-683-4330
ABSTRACT
The occurrence of pharmaceutical and personal care products (PPCPs) in the environment water is of growing concern due to their potential harmful effects on environmental and human. The conventional methods based on the “template” of EPA 1694 method require pre-concentration of large volume of water sample and tedious SPE cleanup, followed by LC-tandem mass spectrometer analysis in order to achieve the low ng/L (ppt) level detection. In this study, we introduce an UHPLC system with an integrated online extraction option coupled to a Bruker EVOQ Elite triple quadrupole mass spectrometer for detection of PPCP’s in water. The Bruker Advance UHPLC OLE system consists of one binary pump and an integrated third pump for online sample preparation. The built-in online extraction requires no additional hardware assembly (LC pump and valve), and can readily detect 1-5 ppt of PPCPs in water by rapidly pre-concentrating 0.5 mL drinking water sample. The current ongoing work is focused on expanding the targeted PPCP list in one analytical run by further optimizing the pre-concentration step and improving chromatographic separation, which will be applied on the water samples from the local lakes in the bay area.