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From Helium to Hydrogen: GC-MS Case Study on SVOCs in Water
Oral Presentation
Prepared by D. Cardona1, A. Semyonov2, E. Phillips3
1 - Thermo Fisher Scientific, 2215 Grand Avenue Pkwy, Austin, Texas, 78728
2 - Thermo Fisher Scientific, 2215 Grand Avenue Pkwy, Austin, Texas, 78728
3 - Thermo Fisher Scientific, 2215 Grand Avenue Pkwy, Austin, Texas, 78728
Contact Information: dwain.cardona@thermofisher.com; 5122511597 ext 1463
ABSTRACT
The global helium shortage and price increase cause more and more laboratories to migrate to hydrogen as a carrier gas. This transition is easy for the GC methods utilizing FID, TCD, ECD, and other non-mass-selective detectors. However, for the GC-MS methods, especially complex and regulated ones, migration to hydrogen carrier gas presents significant challenges. In addition to the changes in chromatographic conditions due to the physical property differences of hydrogen, its chemical reactivity brings about chemical reactions in the mass spectrometer’s ion source that do not occur with helium.
The analysis of semi-volatile organic compounds (SVOCs) in wastewater by EPA Method 8270 involves identification and quantitation of more than 120 analytes of varying chemical structure, polarity and volatility. The diversity of the analytes in this method and the requirement to meet DFTPP tuning criteria present particular challenges when migrating from helium to hydrogen carrier.
We will present and compare data of fast GC-MS analysis of SVOCs performed on TRACE 1310 GC coupled to ISQ single quadrupole mass spectrometer utilizing helium and hydrogen carrier gases. Key modifications to both GC and MS set up in hardware and methods necessary for successful migration to hydrogen carrier gas will be discussed and effect of each parameter on the data quality will be demonstrated. The final, optimized and validated method fully migrated to hydrogen carrier gas with improved peak shape, resolution, run time, and sensitivity will be presented. Study on instrument detection limits and robustness will be presented alongside ion ratio stability and MS library search reliability.
Oral Presentation
Prepared by D. Cardona1, A. Semyonov2, E. Phillips3
1 - Thermo Fisher Scientific, 2215 Grand Avenue Pkwy, Austin, Texas, 78728
2 - Thermo Fisher Scientific, 2215 Grand Avenue Pkwy, Austin, Texas, 78728
3 - Thermo Fisher Scientific, 2215 Grand Avenue Pkwy, Austin, Texas, 78728
Contact Information: dwain.cardona@thermofisher.com; 5122511597 ext 1463
ABSTRACT
The global helium shortage and price increase cause more and more laboratories to migrate to hydrogen as a carrier gas. This transition is easy for the GC methods utilizing FID, TCD, ECD, and other non-mass-selective detectors. However, for the GC-MS methods, especially complex and regulated ones, migration to hydrogen carrier gas presents significant challenges. In addition to the changes in chromatographic conditions due to the physical property differences of hydrogen, its chemical reactivity brings about chemical reactions in the mass spectrometer’s ion source that do not occur with helium.
The analysis of semi-volatile organic compounds (SVOCs) in wastewater by EPA Method 8270 involves identification and quantitation of more than 120 analytes of varying chemical structure, polarity and volatility. The diversity of the analytes in this method and the requirement to meet DFTPP tuning criteria present particular challenges when migrating from helium to hydrogen carrier.
We will present and compare data of fast GC-MS analysis of SVOCs performed on TRACE 1310 GC coupled to ISQ single quadrupole mass spectrometer utilizing helium and hydrogen carrier gases. Key modifications to both GC and MS set up in hardware and methods necessary for successful migration to hydrogen carrier gas will be discussed and effect of each parameter on the data quality will be demonstrated. The final, optimized and validated method fully migrated to hydrogen carrier gas with improved peak shape, resolution, run time, and sensitivity will be presented. Study on instrument detection limits and robustness will be presented alongside ion ratio stability and MS library search reliability.