Follow NEMC
 |
 |
 |
Advances in Interference Removal for Accurate Arsenic Analysis in Food and Beverages
Oral Presentation
Prepared by S. Wilbur
Agilent Technologies, 472 Redtail Lane, Lopez Island, WA, 98261
Contact Information: steven.wilbur@agilent.com; 425-356-6333
ABSTRACT
Arsenic contamination of food and beverages has become a heated topic of discussion in media outlets and many households across the globe. Arsenic, like many other toxic analytes, exists in many forms, some of which are very toxic (As3+, As5+) while many others are inert. It has thus become very critical to identify the levels and types of species that exists in a particular sample in order to differentiate between the non-toxic and toxic species.
Challenges, however, exist in arsenic analysis due to the presence of isobaric interferences, which left uncontrolled, will bias the data. As such, collision/reaction cell (CRC) is employed for removal of these polyatomic interferences. Most polyatomic interferences are easily removed via a collisional or reactive mode however, doubly charged interferences are mostly left uncontrolled thus biasing the result. Critical to each analysis is understanding and ultimately identifying the types of interferences present, which would allow for their effective removal. Controlling what enters the cell is crucial to controlled chemical reactions thus allowing for accurate, precise and unbiased data in reaction mode.
Here we are providing a systematic approach to understanding the magnitude of these isobaric interferences and how to effectively approach their removal. Comparative analysis between single quad mass spectrometer and MS/MS technology will also be presented.
Oral Presentation
Prepared by S. Wilbur
Agilent Technologies, 472 Redtail Lane, Lopez Island, WA, 98261
Contact Information: steven.wilbur@agilent.com; 425-356-6333
ABSTRACT
Arsenic contamination of food and beverages has become a heated topic of discussion in media outlets and many households across the globe. Arsenic, like many other toxic analytes, exists in many forms, some of which are very toxic (As3+, As5+) while many others are inert. It has thus become very critical to identify the levels and types of species that exists in a particular sample in order to differentiate between the non-toxic and toxic species.
Challenges, however, exist in arsenic analysis due to the presence of isobaric interferences, which left uncontrolled, will bias the data. As such, collision/reaction cell (CRC) is employed for removal of these polyatomic interferences. Most polyatomic interferences are easily removed via a collisional or reactive mode however, doubly charged interferences are mostly left uncontrolled thus biasing the result. Critical to each analysis is understanding and ultimately identifying the types of interferences present, which would allow for their effective removal. Controlling what enters the cell is crucial to controlled chemical reactions thus allowing for accurate, precise and unbiased data in reaction mode.
Here we are providing a systematic approach to understanding the magnitude of these isobaric interferences and how to effectively approach their removal. Comparative analysis between single quad mass spectrometer and MS/MS technology will also be presented.