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The FDA Perspective
Oral Presentation
Prepared by C. Sack
US Food and Drug Administration, 11510 W 80th, Lenexa, Kansas, 66214
Contact Information: chris.sack@fda.hhs.gov; 913-752-2182
ABSTRACT
The FDA pesticide program must meet the challenge of analyzing thousands of pesticides and industrial chemicals at extreme (ppb → ppm) levels in essentially infinite matrices with complexities ranging from water to feeds/foods/herbals; and, in most cases, the analysis must be completed within day for as many as 50 samples per day. To meet this challenge the FDA pesticide program incoporates both targeted and screening analytical approaches. Using the targeted approach, pesticides are analyzed and quantitated against standards for over 240 compounds by LC-MS/MS in 15 minutes, and more than 200 pesticides by GC-MS/MS in 20 minutes. Each sample is additionally screened to detect over 650 pesticides using full scan GC-MS coupled with spectral deconvolution against standardized MS spectra and retention indices. Looking to the future, FDA is working to expand pesticide and toxin coverage by additionally screening with LC coupled with high resolution mass spectroscopy. Also, under evaluation is a procedure to streamline import sample processing by prescreening pesticides and toxins on the surface of raw agricultural commodities using ambient pressure desorption with high resolution mass spectrometry at the port of entry.
Oral Presentation
Prepared by C. Sack
US Food and Drug Administration, 11510 W 80th, Lenexa, Kansas, 66214
Contact Information: chris.sack@fda.hhs.gov; 913-752-2182
ABSTRACT
The FDA pesticide program must meet the challenge of analyzing thousands of pesticides and industrial chemicals at extreme (ppb → ppm) levels in essentially infinite matrices with complexities ranging from water to feeds/foods/herbals; and, in most cases, the analysis must be completed within day for as many as 50 samples per day. To meet this challenge the FDA pesticide program incoporates both targeted and screening analytical approaches. Using the targeted approach, pesticides are analyzed and quantitated against standards for over 240 compounds by LC-MS/MS in 15 minutes, and more than 200 pesticides by GC-MS/MS in 20 minutes. Each sample is additionally screened to detect over 650 pesticides using full scan GC-MS coupled with spectral deconvolution against standardized MS spectra and retention indices. Looking to the future, FDA is working to expand pesticide and toxin coverage by additionally screening with LC coupled with high resolution mass spectroscopy. Also, under evaluation is a procedure to streamline import sample processing by prescreening pesticides and toxins on the surface of raw agricultural commodities using ambient pressure desorption with high resolution mass spectrometry at the port of entry.